• Backed by over 300 years of documented indigenous use
  • Non-habit forming, well tolerated

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Study is the First to Test the Activity of Sceletium tortuosum on Brain Activity and the Fi
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  • Anti-stress
  • Anti-anxiety
  • Serenity
  • Energy


The many benefits of Sceletium Tortuosum include:

  • Backed by over 300 years of documented indigenous use
  • Used traditionally to induce calm, and reduce stress: it is experiential
  • Numerous physician-documented case studies validate its benefits
  • Two therapeutic clinical studies are underway to substantiate claims
  • Backed by an extensive safety data, including a Phase 1 human safety study
  • Promotes calming to help cope with the stresses of daily life
  • Non-habit forming, well tolerated
  • Promotes a sense of calm to improve onset and quality of sleep
  • Proprietary standardized extract; identity preserved, cultivated elite plant selection
  • Ecologically sustainable plant production
  • Socially responsible through equitable benefit-sharing
  • Patented in the US and other countries for its benefits and active compounds

Depression and stress, though typically not regarded as diseases, are recurrent life threatening heterogeneous disorders associated with diverse behavioral, psychological and physiological symptoms. Reports have indicated that approximately 30% of patients afflicted with these conditions do not respond to conventional medical operations. Plants that produce molecules exhibiting immune‐modulation properties have therefore become attractive targets for the development of new drugs for analysis of central nervous system (CNS) disorders.

Sceletium tortuosum has also been targeted due to its application in the help of neurological disorders and neuro-degenerative diseases. The species, indigenous to South Africa, is a decumbent perennial sub‐shrub that forms part of the dry Karoo vegetation of the south‐western regions of the country. The plant is commonly referred to as “kanna” or “kougoed” by local communities and is traditionally used to remedy CNS‐related conditions. In addition, it is used in psycho- active preparations for quenching thirst, for relief of hunger and as a colic remedy for babies. Phytochemical studies of S. tortuosum have shown that alkaloids, commonly referred to as “mesembrine- type alkaloids” (mesembrine, mesembrenone, mesembrenol and mesembranol) are responsible for the psychoactive properties of the plant. The ability of these alkaloids to remedy CNS‐related disorders has been associated with their role in serotonin re-uptake inhibition and phosphodiesterase 4 (PDE4) inhibition. Buy Zembrin® Sceletium Tortuosum

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