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Zembrin is Protected – Only patented Sceletium in the world Granted U.S. patent #6,288,104
-Two additional U.S. patents pending Product sourced from patent holders. – Only Sceletium extract licensed for commercialization Sceletium export permit granted: Permit No. IEP 0001 Exclusive endorsement by the indigenous community. – Zembrin® is patented in the United States, Australia, and 5 other countries for its benefits and active compounds. Intersting Facts: 1st ever export permit from South African government, full compliance under the Biodiversity Act. International best practice benefit-sharing agreement with South African San Council Endorsed by indigenous people with the exclusive use of their trademark for a Sceletium product Biodiversity leadership hailed at UN Nagoya conference by Minister of the Environment Ecologically sustainable plant production & cultivation, to EU and Global GAP Reliable supply chain and validated QC through own propagation & production


Clinical Safety Study: A RCT evaluation of 25mg of Zembrin® in 36 healthy adult volunteers over a 12 week period.   – Zembrin® was safe and well tolerated – Unsolicited positive effects reported on mood, stress, and anxiety In vivo: no chronic toxicity 90 day study at 70 mg/kg per day In vivo: no acute toxicity at 5000 mg/kg In vitro: no toxicity; Ames test, Micronucleus, hERG SCELETIUM: EFFICACY IN-VIVO Dementia in dogs: 10mg/kg at night decreased excessive barking. Hirabayashi et al. 2002. Hirabayashi, M., Ichikawa, K., Fukushima, R., Uchino, T., Shimada, H., 2002. Clinical application of South African tea on dementia dog. Japanese Journal of Small animal Practice 21, 109–113 [Japanese]. Decreased cage-stress and travel stress in cats: 10mg/kg- 100mg/kg. Hirabayashi et al. 2004. Hirabayashi, M., Ichikawa, K., Yoshi, A., Uchino, T., Shimada, K., 2004. Clinical effects of South African tea for Cat. Japanese Journal of Small Animal Practice

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Interesting Facts

Historically, at least as far back as the 17th century, the Little Karoo and Namaqualand were inhabited by nomadic African groups of Khoi and San. Though there are a number of cultural similarities and differences between Khoi and San, the utilization of Sceletium species appears to be one such case of cultural convergence between the Khoi and San, as is its symbolic connections with the land. The symbolic significance of the land in the San culture as the trance animal par excellence is well known. It is also a predominant and widely recurring feature of San rock art in southern Africa. Quite apart from its economic importance as one of the major objects of the hunt, it was symbolically linked to fertility, marriage, rainmaking, divination, dancing, trance and healing. The Khoi of the Little Karoo referred to Sceletium and the eland by the same term ‘Kanna’. Hence, the derivation of

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History Of Sceletium Tortuosum

Sceletium Tortuosum can be used in healing depression, including major depressive disorder, anxiety, social phobia, and low libido. It is also used to facilitate the psycho therapeutic process and for support in alcoholism rehabilitation and smoking cessation. History of use Sceletium tortuosum has one of the oldest documented histories of herbal use of any South African medicinal plant. The earliest written records of the use of this plant date to 1662 and 1685. In 1738 Kolben stated that Sceletium was “the greatest cheerer of the spirits, and the noblest restorative in the world”. The vernacular name “kougoed” for Sceletium tortuosum was first documented in 1830, alluding to the well-known Nama practice of chewing this plant. In 1928 Laidler stated that Sceletium was prized by Europeans as a ginseng-like herb. More recently, in 1971, Herre reported that storekeepers in Namqualand bought Sceletium tortuosum from the locals and resold it. In 1994,

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New Clinical Trial Uses fMRI to Demonstrate Stress Reduction after Acute Administration of Zembrin

Study is the First to Test the Activity of Sceletium tortuosum on Brain Activity and the First to Study the Effects of a Dual PDE4 and 5-HT Reuptake Inhibitor in Humans   PLT Health Solutions, Inc. and HG&H Pharmaceuticals Pty. Ltd. announced the publication of a clinical trial that used functional Magnetic Resonance Imaging (fMRI) technology to study the effects of acute (short term) supplementation with Zembrin® on the “threat circuitry” of the human brain. The double-blind placebo-controlled crossover trial conducted with 16 healthy university students showed that 25 mg of Zembrin reduced anxiety-related activity of the amygdala and its associated anxiety circuitry within 2 hours of administration. These results provide the first evidence for the areas of brain where Zembrin’s anti-anxiety activity acts, and confirmation of the potential for Zembrin to help in the management of stress.   Zembrin is the first patented, standardized and clinically studied extract of

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Exploding head syndrome, stress and Sceletium Tortuosum

Do you suffer from Exploding head syndrome? No, this is not a joke. Exploding head syndrome is a rare form of hypnagogic (the period of drowsiness immediately preceding sleep) auditory hallucination in which the person experiences a loud bang or explosion in their head similar to a real-life bomb exploding. It could also be like a gun firing, a clash of cymbals, ringing, or any other form of loud noise. But, there is no noise. It all transpires inside their head.   It usually happens just at the onset of, or within an hour or two of sleep. It is not necessarily the result of a dream. There is no pain involved however, sufferers frequently feel a sense of fear and anxiety and an elevated heart rate, difficulty in breathing, Attacks may also be accompanied by perceived flashes of light. Exploding head syndrome is also known as “auditory sleep starts”.

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Scared S***Less? Sceletium Tortuosum

Zembrin and anxiety. Did you know that 26% of adults have left over fears from scary movies in their childhood? When someone says that some movie scared the Sh*t out of them they are not just seizing the opportunity to use a favorite time honored invective. They are potentially telling the truth. Here’s how it works: when something happens I our life to make us experience great fear it triggers the brain to release epinephrine (hormone/neurotransmitter) throughout the body. This stimulates the sympathetic nervous system which affects all different parts of the body. Epinephrine triggers a different tonality in the anus causing it to dilate. The sympathetic nervous system also triggers the bladder causing a urine discharge as well. Epinephrine also causes the heart to race, the hair to stand on edge and the pupils in the eye to dilate. If you ever feel that scared it is a good

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This Ancient Herbal Remedy Can Improve Depression And Anxiety In Just A Few Days – Safer And Quicker Than Conventional Antidepressants

Stress, anxiety and depression seem to be a modern plague. Doctors are writing an incredible five times more prescriptions for antidepressant drugs now than they were 20 years ago; but dishing out more medication has done little or nothing to improve the situation. In fact the problem is still growing, with latest figures from the Office for National Statistics showing that one in every five adults in the UK now suffers from anxiety or depression¹.   Antidepressant drugs may be more of a problem than a solution. They are often ineffective and their list of side effects is enormous; the more serious of these include thoughts of suicide or self-harm, a potentially fatal drop in blood sodium levels (hyponatraemia), a dangerous rise in blood pressure, erectile dysfunction, diabetes, anxiety and digestive problems.   Dr David Healy is professor of Psychological Medicine at Cardiff University Medical School. He has described antidepressants

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Acute Effects of Sceletium tortuosum (Zembrin)

a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus David Terburg1,2,5, Supriya Syal2,3,5, Lisa A Rosenberger¹, Sarah Heany², Nicole Phillips², Nigel Gericke4, Dan J Stein² and Jack van Honk1,2 ¹Department of Psychology, Utrecht University, Utrecht, The Netherlands ²Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa ³Department of Psychology, University of Toronto, Toronto, ON, Canada 4HG&H Pharmaceuticals (Pty) Ltd, Bryanston, South Africa Correspondence: Dr D Terburg, Department of Psychology, Utrecht University, Heidelberglaan 2, Utrecht 3584 CS, The Netherlands, Tel: +31 30 253 3043, Fax: +31 30 253 4511, E-mail: d.terburg@uu.nl 5These authors contributed equally to this work. Received 26 February 2013; Revised 22 July 2013; Accepted 22 July 2013 Accepted article preview online 1 August 2013; Advance online publication 21 August 2013 Abstract The South African endemic plant Sceletium tortuosum has a long history of traditional use

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Moving beyond Hoodia

Sceletium & devil’s Claw bring focus back to Africa Do exotic plants from Africa offer the alluring promise of improved health for consumers in the developed world? You betcha. With long histories of usage by indigenous peoples, many of these plants have documented and attractive me­dicinal properties that marry well to the pre­vailing health conditions reaching epidemic proportions in Western society. But the days of simply finding a new plant, wild harvesting it, and then exporting the raw material to in­ternational markets are long gone. Between newly developed standards for plant identification, sustainable cultivation and protections of indigenous plant knowledge to varying regulatory hurdles around the world, the commercialization of African herbs can be a long daunting process.   A few companies, however, are rising to the challenge, New ingredients, such as sceletium (sceletium tortuosum) and devil’s claw (harpagophytum procumbens) are generating strong interest, have compelling safety and efficacy documentation

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