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CHEMISTRY

Learn more about how the science behind this amazing product works
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4 major alkaloids :

mesembrine, mesembrenone, mesembrenol, mesembranol

  • Highly variable total alkaloid content 0.05 – 2.3%
  • Highly variable alkaloid composition (eg. mesembrine may be 0-90% of total alkaloids)
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STANDARDIZED TO DEFINED HPLC PROFILE

  • Mesembrenol + Mesembrenone NLT
  • 70% of total alkaloid Mesembrine NMR
  • 20% of total alkaloid Mesembranol : present
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MECHANISM OF ACTION

Greater than 80% inhibition of radioligandbinding:

  • PDE4
  • GABA
  • PDE3
  • 5-HT transporter (SERT)
  • CCK1
  • δ2-opioid
  • μ-opiod
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ZEMBRIN® PDE4 INHIBITION

cAMP / cGMP regulation crucial in memory- related processes
PDE4 inhibitors are being researched for :

  • Cognitive Function
  • Neuroprotection
  • Depression
  • Alzheimer’s
  • Inflammation
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Dual inhibition: (Patent pending)

  • 5-HT transporter (IC50: 4.3 g/ml)
  • SSRI
  • PDE4 (IC50: 8.5 g/ml)