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SAFETY

Clinical Safety Study: A RCT evaluation of 25mg of Zembrin® in 36 healthy adult volunteers over a 12 week period.

  – Zembrin® was safe and well tolerated
– Unsolicited positive effects reported on mood, stress, and anxiety

  • In vivo: no chronic toxicity 90 day study at 70 mg/kg per day
  • In vivo: no acute toxicity at 5000 mg/kg
  • In vitro: no toxicity; Ames test, Micronucleus, hERG

SCELETIUM: EFFICACY IN-VIVO

Dementia in dogs: 10mg/kg at night decreased excessive barking.
Hirabayashi et al. 2002. Hirabayashi, M., Ichikawa, K., Fukushima, R., Uchino, T., Shimada, H., 2002. Clinical application of South African tea on dementia dog. Japanese Journal of Small animal Practice 21, 109–113 [Japanese].

Decreased cage-stress and travel stress in cats: 10mg/kg- 100mg/kg.
Hirabayashi et al. 2004. Hirabayashi, M., Ichikawa, K., Yoshi, A., Uchino, T., Shimada, K., 2004. Clinical effects of South African tea for Cat. Japanese Journal of Small Animal Practice 23, 85–89 [Japanese].

Dementia in dogs and cats: (31 dogs, 2 cats). 2- 90mg/kg for 5- 180 days. All animals except one showed some improvement. Sceletium was “remarkably effective” in 12 animals.
Hirabayashi et al. 2005 Hirabayashi, M., Ichikawa, K., Yoshi, A., Shimada, K., Uchino, T., 2005. Clinical effects of South African Tea for dementia animal. Japanese Journal of Small Animal Practice 24, 27–31 [Japanese].